Stem cell and its derivatives as drug delivery vehicles: an effective new strategy of drug delivery system
نویسندگان
چکیده
Researches on drug delivery system (DDS) have made incredible progress, but there are still problems such as insufficient targeting and undesirable treatment efficiency. To improve the above problems, a stem cell-based DDS was developed. Stem cell its derivatives (cell membranes, extracellular vesicles/exosomes) been used important vehicles in of number human key diseases, genetic cancer so on. For cells highly express chemokine receptors CCR2 CXCR4, which can specifically bind to chemokines or cytokines produced tissue injury sites, they exhibit centripetal homing properties, is reason why employed vehicles. effectively enhance efficiency drugs with low immunogenicity. We review extremely prominent superiority Especially summarize different strategies major application anti-tumor, anti-inflammatory, repair regenerative medicine fields. The challenges targeted how their targeting, selectivity, effectiveness, reducing immunogenicity, fully exerting immunomodulatory effects. think derivatives-based will demonstrate significant prospects future.
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ژورنال
عنوان ژورنال: All life
سال: 2021
ISSN: ['2689-5293', '2689-5307']
DOI: https://doi.org/10.1080/26895293.2021.1967202